Isabelle Mann was born a teachers' daughter in Göttingen, Germany, to Friedlinde (Helweg) and Karlotto Mann. She spent her early years in Wiesbaden, Germany, and was later raised bilingually in Addis Ababa, Ethiopia. This intercultural background affords her the flexibility to work in any setting around the globe.
She studied acting at ‘Reduta Acting and Drama School’ in Berlin, and graduated in 2002. Her post-graduation career began on stage in Berlin and Bremen, and she has always retained her association with the theatre.

She had her film debut as the lead actress in the horror movie ‘Der Kali Prozess’, in which she worked with award-winning film-maker Andreas Marschall.

Isabelle Mann moved to Tel Aviv, Israel, in 2006 where she worked in several theatre productions at the Jewish Arab Theatre and the Susan Dellal Theatre. She worked with Robert Castle at the International Theatre New York from 2009 until 2011, and again in 2024.

She was nominated for ‘Best Supporting Actress’ at the 2015 Maverick Movie Awards, USA, for the multi-award-winning motion picture ‘37’, in which she worked with the talented director Chris Brügge.

She has starred in the international feature film ‘Hello Au Revoir’, directed by Jason Croot, and in the ARD prime time series ‘Praxis mit Meerblick’, directed by Joseph Orr.

In 2021, Isabelle Mann was cast for Germany's most successful long-running series ‘Gute Zeiten, schlechte Zeiten’.

The critically acclaimed arthouse film ‘The Food on the Table’, directed by Ismene Daskarolis and featuring Isabelle Mann in the lead role, was screened in 2024 at the prestigious Berlin International Film Festival, popularly known as the ‘Berlinale’.

Isabelle Mann has studied film acting and American acting techniques with some of the most renowned acting coaches of our time, Susan Batson and Robert Castle. 

Isabelle Mann currently lives in Berlin.